PhD position that is part of ComeInCell- EU Horizon Europe Funded Doctoral Network

https://www.comeincell.org/dc14-how-can-membranes-control-condensate-formation-and-location/

The Sorkin Lab www.sorkinlab.sites.tau.ac.il/ has extensive experience in studying membrane remodelling processes using mechanical single-molecule techniques. In this project, we aim to reveal the effect of membrane composition and membrane phase separation on condensate formation by AFM imaging and force spectroscopy, characterizing the sub-saturated phase and condensate nucleation steps. The effects of membrane tension on condensate association will be tested by stretching supported membranes or inducing area changes by photo-sensitive lipids. This research will elucidate the effects of membrane tension and composition on condensate formation and association, with findings expected to enhance our understanding of condensate-membrane interactions in both synthetic systems and cellular models, potentially providing new methods for targeting condensates to specific membrane locations.

The project will involve secondments at CSIC (Rivas Group) to learn about protein condensate preparation, and at the Max Planck Institute for Colloids and Interfaces (Dimova Group) to learn about preparation of asymmetric membranes with photo-responsive lipids.

Desirable Applicants should hold or expect to attain, as a minimum a MSc or equivalent, in Biophysics, Physics, Chemistry, Bioengineering or related area.

Research project carried out in at least one of the above disciplines. AFM or Microscopy experience (optical, confocal) is an advantage.  A demonstrated knowledge of at least one of the following: membrane biophysics, biomolecular condensates, lipid chemistry, colloidal physical chemistry, soft matter

• Before applying, please check the eligibility criteria HERE
• The period of secondment can be flexible because of the current political circumstances.
• This project requires geographic mobility. However, in exceptional and merit-based cases, Israeli candidates will also be considered.
• To apply and for further information, contact Raya Sorkin by sending an email to rsorkin [at] tauex.tau.ac.il