Postdoctoral Research Fellow in Organoid Models

Join the innovative laboratory of Prof. Yaakov Nahmias at Hebrew University in Jerusalem, collaborating with Tissue Dynamics, a pioneering biotechnology company. We delve into revolutionary research and drug discovery, specializing in three-dimensional human organoids, providing invaluable insights into human-specific mechanisms.

The Position:

We are excited to offer a unique Postdoctoral Fellow opportunity in a groundbreaking collaborative project between Tissue Dynamics and the Lab of Professor Yaakov Nahmias. This position is at the forefront of rare disease research, combining innovative stem cell techniques, patient-derived cellular models, CRISPR technology, and advanced molecular tools. The successful candidate will play a pivotal role in developing and characterizing new organoid models that mimic the pathophysiology of rare diseases, contributing to a deeper understanding and potential therapeutic approaches.

About Tissue Dynamics:

Tissue Dynamics is a leader in the field of tissue engineering and regenerative medicine. Our focus is on developing drugs using state-of-the-art sensor embedded 3D organoid models that accurately replicate human organ systems. These models are used to study disease mechanisms, test drug efficacy, and explore novel therapeutic interventions.

About Prof. Yaakov Nahmias' Lab:

The laboratory of Professor Yaakov Nahmias is renowned for its groundbreaking work in the field of cellular biology and bioengineering. Prof. Nahmias' team specializes in leveraging advanced techniques like CRISPR gene editing, high-resolution imaging, and computational biology to understand and manipulate cellular processes. The lab has a strong track record of pioneering research in the development of patient-derived cell models for studying complex diseases.

Recent Collaborative Publications:

·        Cohen, A. et al. (2021) ‘Mechanism and reversal of drug-induced nephrotoxicity on a chip’, Science Translational Medicine, 13(582). doi:10.1126/scitranslmed.abd6299.

·        Ghosheh, M. et al. (2023) ‘Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids’, Nature Biomedical Engineering, 7(11), pp. 1493–1513. doi:10.1038/s41551-023-01071-9.

·        Ioannidis, K. et al. (2022) ‘Aminoglycoside-induced lipotoxicity and its reversal in kidney on chip’, Lab on a Chip, 22(23), pp. 4469–4480. doi:10.1039/d2lc00825d.

The Role:

·        Develop and optimize organoid models using stem cells and patient-derived cells.

·        Employ CRISPR and other molecular tools for targeted genetic modifications.

·        Utilize advanced characterization methods to analyze organoid models.

·        Collaborate with an interdisciplinary team of scientists and researchers.

·        Contribute to high-impact publications and present findings at international conferences.

Who You Are:

·        Holder of a recent PhD in biophysics, tissue engineering, cellular biology, pharmacology, or a related field.

·        Demonstrated expertise in stem cell culture, CRISPR technology, and molecular biology techniques.

·        Proven track record of scientific research with publications in reputable journals.

·        Strong analytical skills and proficiency in data interpretation.

·        Excellent communication and teamwork abilities.

Joining Our Community:

This Postdoctoral Fellowship Program of Tissue Dynamics is a unique opportunity to engage in high-impact, interdisciplinary research. Fellows benefit from mentorship by leading scientists, access to state-of-the-art facilities, and participation in a dynamic scientific community. The program encourages publishing in top-tier journals and offers various platforms for professional development and networking.

Equal Opportunity:

Tissue Dynamics and Prof. Yaakov Nahmias' Lab are equal opportunity employers. We celebrate diversity and are committed to creating an inclusive environment for all employees.