Doctoral and Post doctoral students

A three to four-year doctoral or postdoctoral position is currently available in the laboratory of Prof. Roee Gutman, Laboratory of Integrative Physiology, Tel-Hai University, Israel (https://www.migal.org.il/en/Roee-Gutman, https://www.linkedin.com/in/roee-gutman-0889208/).

The successful candidate will lead a research project to evaluate the neuromolecular mechanisms underlying the entrainment of the endogenous circadian pacemaker to non-matching environmental photic cycles under obesogenic conditions (See our latest publication: https://doi.org/10.1096/fj.202502574RR).

We plan to explore the central cellular, molecular, and epigenetic adaptations in the master circadian pacemaker (Suprachiasmatic Nucleus, SCN) that mediate parametric entrainment. We will utilize single-cell RNA sequencing (scRNA-seq) to identify cell-type-specific transcriptional shifts and clock-gene network plasticity within the SCN under varying T-cycle regimens. We will also analyze genome-wide DNA methylation patterns in the SCN to evaluate how parametric entrainment permanently reprograms intrinsic rhythmicity and aftereffects. In addition, sexual Dimorphism will be studied to resolve sex-dependent differences in circadian entrainment kinetics and SCN neurochemistry.

The successful candidate will be expected to produce first-authored papers, develop synergistic projects, and train graduate students in the lab. Applicants must have an MSc. or Ph.D. in a relevant field (e.g., Systems Physiology, Neurobiology, Bioinformatics, Computational Biology, or related fields). Candidates should have hands-on experience in Big Data analysis and computational tools (e.g., R/Python, scRNA-seq pipelines, epigenetic analysis). This is a one-year full-time position with the possibility of renewal for three to four years, pending satisfactory performance. The position's start date is flexible, but we hope to employ someone by December 2026.

To apply for this position, please submit a PDF containing 1) a letter of interest describing relevant experience, goals, and research interests, 2) a curriculum vitae, and 3) names and e-mail addresses for three or more references. Please submit the PDF to Prof.  Roee Gutman ([email protected]).