Post-doc

Postdoctoral Position in Gene Expression & RNA Biology

A postdoctoral position is available in the laboratory of Prof. Mordechai (Motti) Choder at the Faculty of Medicine. The lab uses yeast as a powerful model system to uncover fundamental principles of intracellular communication that integrate all stages of gene expression— from transcription to mRNA fate— into a unified regulatory system.

The specific project focuses on uncovering the molecular mechanisms by which mRNA degradation factors function in transcription activation (yes—this is not a mistake). The work will explore how these factors operate within phase-separated transcriptional condensates, employing state-of-the-art high-throughput and systems-level approaches.

This research addresses central questions in gene regulation and is highly relevant to cellular adaptation to environmental changes, including stress responses and dynamic signaling states.

The position is ideal for candidates interested in:

·       RNA biology and gene expression regulation

·       Transcription–mRNA decay crosstalk

·       Phase separation and biomolecular condensates

·       Cutting-edge genomic and proteomic methodologies

Selected publications of the group that are relevant to the project:

Cell doi: 10.1016/j.cell.2010.10.033

Cell doi: 10.1016/j.cell.2011.12.005

Cell doi: 10.1016/j.cell.2013.05.012

Nat comm doi: 10.1038/s41467-022-34417-z

Nat comm doi: 10.1038/s41467-019-09199-6

eLife doi.org/10.7554/eLife.90766.1