Bioanalytical Scientist - Maternity leave replacement

Position Summary: We are looking for a highly motivated, focused, and energetic bioanalytical researcher who is seeking experience in a young, dynamic startup environment. This role will be responsible for supporting the activities of drug discovery initiation of pre-clinical studies through the filing of INDs.

About the Company: 1E Therapeutics is a drug development company creating first-in-class RNA-targeting therapeutics based on a proprietary drug discovery platform.

1E's groundbreaking process is uniquely able to identify innovative candidates that address chronic life-threatening indications. 1E already has compounds that address a wide array of indications in multiple therapeutic areas. We are looking for spirited researchers who will be highly engaged in the company's mission to develop novel RNA therapeutics for major unmet medical needs.

Responsibilities:

• Designing, writing and reviewing study procedures/plans, amendments, and schedules that define all bioanalytical activities.
• Executing bioanalytical analysis plans
• Developing and optimizing new strategies to process cellular and tissue samples for analysis by Liquid Chromatography Mass Spectrometry (LC/MS)
• Processing, interpreting, and presenting raw data to enable thoughtful decision making.
• Preparing reports that document all bioanalytical procedures and results.
• Learning and implementing new techniques and technologies, as relevant

Requirements:

• A master’s degree (or higher) in analytical chemistry, organic chemistry (an advantage), biochemistry, or another close scientific field
• At least two years of experience in pharma/biotech
• Hands-on laboratory experience with biological sample extraction and preparation approaches.
• Processing cellular and tissue samples for analysis by Liquid Chromatography Mass Spectrometry (LC/MS) - previous hands-on experience is a must.
• Developing qualitative and quantitative methods and validation (GMP) for the analysis of pharmaceutical products in biological matrices by LC-MS/MS including method troubleshooting - an advantage.
• Proven experience in working with DLS for the characterization of LNPs/liposomes
• Expertise in data analysis, a robust understanding of lipid-based nanoparticle systems and their applications in drug delivery, as well as proficiency in experimental design, execution, and troubleshooting - an advantage.
• Established experience in using ELN
• Ability to work with interdisciplinary project teams, agility learning, communicate clearly, and follow project timelines.