Scientist – Oligonucleotide R&D Chemist

Scientist – Oligonucleotide R&D Chemist

Full Time Professional

Jerusalem - Har Hotzvim

1E Therapeutics is seeking a chemist to join our growing process development team, and take part in the development/analysis of oligonucleotide synthesis and purification. This position requires good understanding of reaction mechanisms as well as developing and optimizing chemistry processes.

Responsibilities

• Develop, design, and execute, DS manufacturing process for oligonucleotides. Develop and implement optimization strategy of robust, scalable and cost-effective manufacturing routes while in compliance with all relevant regulatory standards
• Technology transfer of developed process to GMP production
• Solving challenging development/technical issues
• Manufacturing of R&D batches to be used for pre-clinical studies
• Present data and participate in group discussions 
• Documents research using lab notebooks, prepare and/or review protocols and reports
• Keep up to organic chemistry knowledge by reading literature papers

Qualifications

• Education - MSc in chemistry – Required , PhD – Advantage (Organic Chemistry background – preferred)

• Experience:
• Previous experience in similar position in the industry – Advantage
• Solid phase synthesis (peptide or oligonucleotide) or with nucleoside and nucleotide chemistry – Advantage
• Experience with ÄKTA™ systems - Advantage

• Other:
• High level of English
• Strong accuracy and organizational skills
• Good reporting capabilities
• Strong teamwork skills

1E Therapeutics is a breakthrough, drug development company creating first-in-class RNA-targeting therapeutics based on a proprietary drug design platform.

1E's groundbreaking process has proven uniquely able to develop innovative drugs that address chronic life threatening indications as well as emerging and evolving pathogens. 1E already has lead compounds that address a wide array of indications in oncology, age-related diseases, immunology, anti-microbial resistance, viral infections, and orphan neurological disorders.

Send your CV to [email protected] / [email protected]